Protection against radiation leukemogenesis by repeated injections of immune and nonimmune foreign sera.

Significant inhibition of lymphoid tumor development was observed in X-irradiated strain C57BL mice treated with multiple injections of rat antiserum prepared by im munization of Wistar-Furth or (Wistar-Furth-BN) F, rats with histocompatible lymphomas induced by the radiation leukemia virus (RadLV). However, there was also signifi cant inhibition, relative to phosphate-buffered saline con trols, in C57BL mice that received injections of normal rat serum. This prompted additional experiments in which fetal calf serum or Freund's complete adjuvant were in